MINI REVIEW article
Front. Med.
Sec. Dermatology
Volume 11 – 2024 |
doi: 10.3389/fmed.2024.1466939
Temporarily accepted
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Royal College of Surgeons in Ireland (Bahrain), Al Muharraq, Bahrain
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In recent years, autologous fat transfer (AFT) has gained popularity for reconstructive and cosmetic procedures due to its minimally invasive nature and natural results. However, limitations such as unpredictable fat absorption and safety concerns remain. To address these issues, researchers investigated the incorporation of adipose-derived stromal cells (ADSCs) into fat grafts. Enrichment of fat grafts with ADSCs, often via the stromal vascular fraction (SVF), shows promise in regenerative medicine, although their efficacy is still debated. Some studies suggest that there is no significant difference in outcomes, while others show that ADSCs are more effective in larger grafts. This means that ADSC-enriched grafts may achieve similar results to traditional methods, with tumor preservation being a critical success indicator. Since these cosmetic procedures affect body image and self-confidence, innovative techniques such as ADSC-enriched grafts are crucial to improve clinical outcomes. ADSCs are favored for their abundance of adipose tissue and wound healing properties, which enhance cosmetic results. Patients receiving ADSC-enriched grafts show increased levels of collagen, elastin and CD31 and better graft survival compared to those with traditional fat grafting, reducing the need for repeat procedures. Recent applications in patients with fibrotic facial deformities have shown positive results both aesthetically and psychologically. This mini-review evaluates the efficacy and benefits of ADSC-enriched AFT for facial rejuvenation and reconstruction, focusing on graft retention and overall procedural outcomes.
Keywords:
Autologous fat transfer1, Adipose-derived stem cells (ADSCs)2, Tumor containment3, Regenerative medicine4, Facial rejuvenation5
Received:
July 18, 2024;
Accepted:
October 28, 2024.
Copyright:
© 2024 Ansari Lari, Zumot, Nemrish and Fredericks. This is an open access article distributed according to its terms
Creative Commons Attribution License (CC BY). Use, distribution or reproduction in other forums is permitted, provided the original author or licensor is credited and the original publication in this journal is cited, in accordance with accepted academic practice. Any use, distribution or reproduction that does not comply with these terms is not permitted.
* Correspondence:
Soroush Ansari Lari, Royal College of Surgeons in Ireland (Bahrain), Al Muharraq, Bahrain
Refusal:
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations or the publisher, editors, and reviewers. Any product that may be reviewed in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
