Image source: Natural Science News, 2024
Important findings
- The study by Ben’s Lab Co., Ltd. reviewed BenTooth, a blend of natural products, for the treatment of periodontitis
- BenTooth has shown strong antimicrobial activity against key bacteria that cause periodontal disease
- BenTooth reduced inflammation by reducing levels of specific enzymes and cytokines in laboratory tests
- In a rat model, BenTooth prevented bone loss and promoted bone health, indicating its potential as a treatment for periodontitis
Periodontal disease is a widespread condition that results in significant global morbidity. It is characterized by infection and inflammation of the periodontal tissue due to bacterial pathogens. A recent study conducted by Ben’s Lab Co., Ltd.[1] aimed to evaluate the therapeutic efficacy of BenTooth, a natural product mixture containing burdock root extract, lotus leaf extract and quercetin, against periodontitis both in vitro (in the laboratory) and in vivo (in living organisms). Periodontitis, a common inflammatory disease, begins with a bacterial biofilm, commonly known as dental plaque, that affects both the periodontal ligaments and the bone around the teeth[2]. This condition can lead to the destruction of the supporting structures of the teeth, including the connective tissue and bone[3]. The study by Ben’s Lab Co., Ltd. sought to determine if BenTooth could provide a viable treatment option for this debilitating condition. The study conducted a series of tests to examine BenTooth’s antimicrobial properties and its impact on cellular responses related to inflammation and bone resorption. The results were promising. BenTooth demonstrated strong antimicrobial activity against two key bacterial pathogens, P. gingivalis and S. mutans. These bacteria are known to play an important role in the development of periodontal disease. In the lab, BenTooth was tested on RAW264.7 cells, which are a type of macrophage cell line used to study inflammation. The results showed that BenTooth significantly reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which are enzymes involved in the inflammatory process. In addition, it reduced the levels of inflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), which are usually elevated due to lipopolysaccharide derived from P. gingivalis, a component that triggers inflammation. One of the critical aspects of periodontal disease is bone resorption, which leads to tooth loss. BenTooth has been found to inhibit osteoclastogenesis, the process by which osteoclasts break down bone tissue. This inhibition was mediated by receptor activator of nuclear factor-κB ligand (RANKL), which plays a key role in bone metabolism. The study also included an in vivo component using a rat model of ligation-induced periodontitis. This model mimics the human condition of periodontal disease. In this experiment, rats consuming BenTooth showed a significant reduction in the distance between the cementoenamel junction (CEJ) and the apex of the alveolar bone (ABC), indicating less bone loss. In addition, these rats showed an increased bone volume fraction, suggesting that BenTooth not only prevents bone loss but may also promote bone health. These findings are important because they suggest that BenTooth could be a potential therapeutic candidate for the prevention and treatment of periodontal disease. This is in line with previous studies that have highlighted the importance of managing inflammation and bacterial infection in the treatment of periodontitis[2][3]. In addition, the study supports the idea that improving periodontal health can have wider systemic health benefits, potentially affecting conditions such as cardiovascular disease and diabetes[2]. In conclusion, the study of Ben’s Lab Co., Ltd. provides strong evidence that BenTooth, an edible natural product blend, has significant antimicrobial and anti-inflammatory properties that can moderate the effects of periodontitis. By reducing inflammation and bone resorption, BenTooth offers a promising new approach to managing this common and debilitating condition.
MedicineHealthBiochem
bibliographical references
Main Study
1) Antimicrobial and anti-inflammatory effects of BenTooth: A natural blend of burdock root products, lotus leaf extracts and quercetin for periodontal disease.
Posted on May 30, 2024 (future edition of the Journal)
https://doi.org/10.1016/j.heliyon.2024.e30835
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